The invention discloses a pinyl-3-[4-(substituent)-2-thiazole] hydrazone compounds as well as a synthesis method and an application thereof. The synthesis method of the compounds comprises the steps of by taking alpha-pinene as a raw material, carrying out a hydroboration-oxidation reaction to obtain an isopinocampheol, next, carrying out dehydrogenating under the condition of ice bath to obtain isopinocampheone, reacting the isopinocampheol with thiosemicarbazide to obtain a pinylthiosemicarbazone in the presence of an acidic catalyst, and finally, reacting the pinylthiosemicarbazone with alpha-halogenated aryl ketones to obtain the pinyl-3-[4-(substituent)-2-thiazole] hydrazone compounds. The compounds show excellent sterilizing and bacteriostatic activity on bacteria and fungi, and are highly potential antibacterial and antifungal compounds.