The invention discloses degerming anti-flea powder for pets. The degerming anti-flea powder comprises the following components in parts by weight: 40-80 parts of kieselguhr, 5-15 parts of boric acid powder, 3-10 parts of calcium ion powder, 1-5 parts of cortex meliae extract, 1-5 parts of mint extract, 3-8 parts of radix stemonae extract powder, 1-5 parts of pyrethrum extract, 1-5 parts of radix sophorae flavescentis extract, 2-10 parts of lemon powder and 2-10 parts of cymbopogon citratus powder. Biologically compounded plant preparation is adopted for killing insects, compared with the prior art, the degerming anti-flea powder has the advantages that the operating environment does not need to be taken into consideration, and the safety of pets or people cannot be influenced under any environment. A reagent with specificity capable of killing larvae and adults is used in the environment, one of prevention and cure targets is that fleas on the skins of animals can be cleared, and the other target is that the propagation of the fleas is inhibited, so that the propagation and development process of the fleas can be effectively inhibited, and the touch killing can reach 99%. The degerming anti-flea powder for pets has good application prospect.