A toilet seat cover cleaning device comprises a shell, a lid and a liquid bag. The back of the shell is fixedly mounted on the wall surface and located above a toilet, the lid is mounted on the shell in a capping manner, a pressing part is arranged in the front of the lid, a liquid delivery device comprises a three-way pipe and a rotating handle, an insert is inserted into one end a first pipe of the three-way pipe, a spring is arranged between the insert and the first pipe, one end of a second pipe of the three-way pipe is provided with a clamping column, the rotating handle sleeves the clamping column, an annular fastener is arranged between the clamping column and the rotating handle, a second spring is arranged between the rotating handle and the annular fastener, and the annular fastener is arranged in the second spring in a sleeved manner. One end of a third pipe of the three-way pipe is provided with a liquid outlet. The toilet seat cover cleaning device is simple and convenient to operate during use and easy to mount, can be applied to large public places such as hotels as well as to thousands of households; in the process of using, the toilet seat cover cleaning device is capable of cleaning thoroughly, and manpower resources and water resources are saved; the toilet seat cover cleaning device is easy to detach after being used.