The invention relates to an anti-sticking plate mold pressing coating for an anti-counterfeiting hot stamping film. The anti-sticking plate mold pressing coating is prepared from the substances such as polytetrafluoroethylene, acrylic resin and maleic anhydride in a blending manner. The coating system is low in surface tension, so that action force between a nickel plate and a mold pressing coating is reduced, and the problem of plate sticking in mold pressing is solved. Meanwhile, the strength of the mold pressing coating is reduced by adding the polytetrafluoroethylene. Thus, the cutting performance of the coating is improved, the stability of the product in the mold pressing process and the later hot stamping process is ensured, the operational performance of the product is improved, and the anti-sticking plate mold pressing coating plays an important role in production and application of a holographic anti-counterfeiting film.