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发明公开
CN103804194A 紫檀芪-3,4二羟基苯丙酸酯及其制备方法和应用 有权

紫檀芪-3,4二羟基苯丙酸酯及其制备方法和应用
摘要：
本发明公开了式(I)所示的紫檀芪-3，4-二羟基苯丙酸酯及其制备方法，3，4-二羟基苯丙酸用叔丁基二甲基氯硅烷保护之后，脱除羧基上的叔丁基二甲硅基，接着与紫檀芪进行酯缩合反应，经脱保护后制备得到目的产物。本发明还公开了紫檀芪-3，4-二羟基苯丙酸酯在制备用于预防、延缓或者治疗雄激素受体介导的疾病的药物中的应用，其作为雄激素受体抑制剂，具有广泛应用前景。
摘要（英）：

The invention discloses a pterostilbene-3, 4-dihydroxyl phenylpropionic acid ester as shown in the formula (I) and a preparation method of the pterostilbene-3, 4-dihydroxyl phenylpropionic acid ester. The preparation method comprises the steps of protecting 3, 4-dihydroxyl phenylpropionic acid ester by using tert-butyldimethylsilyl chloride, and then removing tert-butyldimethylsilyl on carboxyl; then, enabling the product and pterostilbene to be subjected to ester condensation reaction; deprotecting to prepare the pterostilbene-3, 4-dihydroxyl phenylpropionic acid ester. The invention also discloses an application of the pterostilbene-3, 4-dihydroxyl phenylpropionic acid ester to the preparation of drugs for preventing, delaying or treating androgen receptor mediated diseases; as an androgen receptor inhibitor, the pterostilbene-3, 4-dihydroxyl phenylpropionic acid ester has wide application prospects.

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