The invention discloses a novel process for producing manganese sulfate by combination of a pyrogenic process and a wet process. The novel process comprises the steps: (1), roasting with anthracite culm to obtain roasted manganese powder; (2), mixing the roasted manganese powder with a secondary solution and/or water for pulping, adding sulfuric acid, adding iron pyrite, performing a thermal reaction, filtering to obtain primary slag and a primary liquid; (3), pulping the primary slag by using water and/or third solution, adding sulfuric acid, adding iron pyrite, performing a thermal reaction, filtering to obtain secondary slag and a secondary liquid, rinsing and filtering the secondary slag to obtain third slag and a third liquid, discharging the third slag; and (4), removing iron from the primary liquid, removing heavy metals, standing, heating and concentrating and crystallizing, dewatering and drying to obtain the manganese sulfate. The novel process has the beneficial effects that (1), the content of full manganese in the manganese slag reaches below 4 percent, the content of tetravalent manganese slag reaches below 0.6 percent, the metal recovery rate reaches above 82 percent, and the mine consumption cost is low; and (2), the main content of a manganese sulfate product reaches above 98.5 percent, the content of a water insoluble is within 0.02 percent, the content of impurities is within 0.3 percent, and the content of heavy metal elements is within 6 ppm.