The present invention relates to Streptomyces phytohabitans, a method for producing new antibiotics Novonestmycin and an application of the Novonestmycin. According to the present invention, the method for producing new antibiotics from the Streptomyces phytohabitans comprises: inoculating Streptomyces phytohabitans HBERC-20821 in a seed culture medium under a strict aseptic condition, culturing for 3-4 days on a shaking table with a temperature of 28 DEG C and a speed of 130-160 rev/min, expanding on the same seed culture medium, culturing for 1-2 days in the same condition, transferring into a fermentation culture medium, fermenting for 4-6 days to obtain a fermentation broth containing the target product, extracting to obtain two substances with broad-spectrum antifungal activity, and carrying out spectral analysis, wherein the two active substances are two new antibiotics with no being reported, and are respectively named Novonestmycin A and Novonestmycin B; and the two new antibiotics Novonestmycin can be made into different formulations so as to be used for prevention and control of fungal plant diseases of crops, and further be used for treatment of fungal diseases of livestock and human.