The invention discloses a fertility recovery method for oyster distant hybrid sterility. The fertility recovery method includes by a distant hybridization mode, performing synchronous gonad treatment on Hongkong oysters and pacific oysters, and performing interspecific oyster hybridization to acquire a highly-sterile filial generation F1; during maturity seasons of filial generation F1 hybrids, analyzing fertility of the hybrids and screening out fertile individuals; by a family or group reproduction mode, performing self-reproduction of the fertile individuals of the hybrids F1 to acquire a secondary filial generation F2; through molecular markers, screening out individuals relatively similar with the hybrids F1 in terms of genotype from completely-fertile hybrids F2 to acquire completely-fertile groups with characteristics of the hybrids F1 so as to realize complete hybrid fertility recovery. By the fertility recovery method, the problem of failure to continue follow-up breeding work due to oyster intersterility frequently caused during distant hybridization is solved, data and references are provided for distant backcross, multiple cross, potential estimation on hybrid offspring breeding and the like of oysters, and possibility is also provided for research and development of new species of the oysters.