The invention discloses a preparation process for a hot-melt butyl sealant for hollow glass. The preparation comprises the following steps: adding polyisobutylene and butyl rubber into a preheated kneading machine for kneading; adding ethylene propylene rubber, calcium carbonate and carbon black into the material when the temperature of the material reaches 150 to 155 DEG C; continuing kneading for 5 to 6 hours at the vacuum degree of 0.03 to 0.05 MPa to obtain a butyl sealant kneading substance; adding the butyl sealant kneading substance into a screw extruder; installing a layer of 40-mesh steel wire filter net to filter impurities and solid particles at the outlet of a screw; packaging the extruded kneading substance by using a packaging film coated with silicone grease; cooling and molding the extruded kneading substance in a cylindrical paper barrel. The hot-melt butyl sealant for the hollow glass prepared by the preparation process has high construction performance at the temperature of 110 to 150 DEG C and has the cold flow rate of almost zero at the temperature of 60 DEG C; the water vapor permeability is extremely low.