The invention relates to an information exchange bus-based secondary safety protective synchronous trans-regional service method, comprising the following steps of (1) packaging the synchronous trans-regional information into an information IEC-61968 report adopting an IEC-61968 series standard definition by an information exchange bus, and performing verb, noun and related number attribute marking on the packaged information; (2), synchronous trans-regional agency service; (3) finishing the secondary safety protective synchronous trans-regional service. The information exchange bus-based secondary safety protection synchronous trans-regional service method avoids the original point-to-point interface mode, the reusability of the interface of an information system is greatly increased, and the method enables the originally disconnected information communication in the trans-regional process to be normally performed, so the efficiency of the information communication is improved and the complexity caused by the single-direction information communication is reduced.