The invention discloses a method and a device for detecting the configuration information of a transformer substation. The method comprises the following steps: setting an SCD (Substation Configuration Description) file including the total station project configuration of the transformer substation; acquiring standard configuration information of an IED (Intelligent Electronic Device) needing to be detected from the SCD file, wherein the standard configuration information serves as first configuration information; acquiring practical configuration information of the IED of detected equipment in an intelligent substation by using MMS (Manufacturing Message Specification) service, wherein the practical configuration information serves as second configuration information; comparing the first configuration information with the second configuration information; outputting a corresponding comparison result. According to the method and the device, online detection of the IED of the detected equipment is realized, the working efficiency is increased, severe potential safety hazards brought to the safe and reliable running of the transformer substation caused by inconsistence of the configuration information are effectively avoided, and the power supply reliability of a power system is enhanced.