The invention belongs to the technical field of rubber production and in particular relates to ozone aging resistant tire tread rubber for a cargo truck. The ozone aging resistant tire tread rubber for the cargo truck is prepared from the following raw materials: butadiene styrene rubber, polyisoprene rubber, sulfur, carbon black N330, paraffin oil, stearic acid, zinc oxide, N-1,4-dimethylphenyl-p-phenylenediamine-5-triazine and N-1,3-dimethylbutyl-p-phenylenediamine. The tire tread rubber has excellent ozone aging resistance, anti-cracking property and no wax, and the problems of reduction of the rubber material viscosity and excessive blooming of rubber material surfaces are avoided.