The invention discloses a tracking and pointing device for laser orientation interference. The tracking and pointing device comprises a laser transmission light path, a pitching servo device and an azimuth servo device, wherein the laser transmission light path sequentially penetrate through the azimuth servo device and the pitching servo device, a spherical seal chamber is connected to the pitching servo device, a laser exit window is arranged in the surface of the spherical seal chamber, a laser exit mechanism and an infrared tracking sensor are installed in the spherical seal chamber, the laser exit optical axis of the laser exit mechanism is the same as the optical axis of a lens of the infrared tracking sensor in pointing direction and corresponds to the laser exit window. The tracking and pointing device not only has a long-distance target tracking function, but also can interfere with a target by sending out laser at a long distance, observe operation effects in real time after the target is interfered by an infrared image, and facilitate further operation, is connected with laser emitters of different characters or carries out different kinds of modulation control on the laser, namely different-character interference on the target can be achieved.