The invention discloses a control rod guide tube, which is inserted in a spacer grid, the control rod guide tube has a hollow tubular structure, and several flow-disturbing openings through the sidewall of the control rod guide tube are provided with the control rod guide tube. According to the flow-disturbing openings on the sidewall of the control rod guide tube, fully mixing of cryogenic fluid on a cold wall surface and hot fluid on a hot wall surface in a cold wall lattice cell occupied by the control rod guide tube can be realized, fluid on the cold wall surface in the cold wall lattice cell can participate in channel heat exchange, thereby CHF performance of the control rod guide tube can be enhanced. The flow-disturbing opening can adjust the fluid resistance when the control rod drops, further the rod-dropping performance of the control rod under accident can be improved. Correspondingly, the invention also provides a fuel assembly possessing the control rod guide tube.