The invention discloses a drawing frame compression roller set with a cleaning device. The compression roller set comprises a driving compression roller, a driven compression roller and the cleaning device, wherein the two ends of the driving compression roller and the two ends of the driven compression rollers are provided with rotary shafts, the roller body of the driving compression roller is coated with a magnetic layer, the magnetic layer is coated with a first abrasion-proof smooth layer, the roller body of the driven compression roller is coated with a metal material layer, the metal material layer is coated with a second abrasion-proof smooth layer, the cleaning device comprises two clamping structures and two cleaning structures, the bottom of each cleaning structure is clamped by the corresponding clamping structure, and the heads of the cleaning structures abut against the outer side of the first abrasion-proof smooth layer and the outer side of the second abrasion-proof smooth layer respectively. According to the drawing frame compression roller set with the cleaning device, cotton wax and impurities adhering to the surfaces of the compression rollers can be timely cleared, the yield of produced wool tops is improved, meanwhile, labor cost is also reduced, and cost is reduced.