The invention relates to glucosamine calcium sulfate and a preparation technology thereof. The glucosamine calcium sulfate is prepared from the following raw materials: 286 Kg of glucosamine hydrochloride (equal to 85 Kg of anhydrous calcium sulfate), 108 Kg of calcium sulphate dehydrate, 1205 L of deionized water and 665 L of hydrochloric acid, wherein glucosamine hydrochloride is powdery particles with a particle size of 10-200 meshes, and calcium sulphate dehydrate is powdery particles with a particle size of 10-200 meshes. The beneficial effects comprise that: the glucosamine calcium sulfate and the preparation technology not only help to solubility in solution, but also help to enable calcium to be relatively easy to absorb after glucosamine calcium sulfate is eaten by a person.