The invention discloses a scheduling request (SR) processing method, an E-UTRAN NodeB (eNB), and user equipment (UE). The method comprises the following steps that: the eNB determines whether an SR is multiplexed to a sounding reference signal (SRS); and the eNB informs the UE of the determination result. With the method, the eNB and the UE, a problem that the flow of the system is reduced seriously because of multi-time downlink subframe retransmission caused by inaccuracy of feedback information due to reduction of a code channel number for positive acknowledgement (ACK) sending based on multiplexing of the SR and the ACK can be solved. And furthermore, the method for SR processing is brought forward; and the system flow can be well controlled because the ACK bit number does not occupied.