The invention discloses a health-care chili sauce and a preparation method of the health-care chili sauce. The health-care chili sauce comprises, by weight, angelica sinensis, Chinese yam, ligustrum lucidum ait prepared with wine, radix polygoni multiflori preparata, fructus lycii, cornus prepared with wine, ganoderma lucidum, purple-leaf ginseng, tartary buckwheat tea, garlic, onion, a sweetening agent, citric acid, dry chili, ginger, soybean paste, chicken essence, five spice powder, table vinegar, cooking oil and table salt. The preparation method comprises the steps of selection of raw materials, washing, spin-drying, preparation of mixed powder, preparation of chili paste, treatment of the garlic and the ginger, preparation of a chili raw material, stewing, tinning, sterilization and cooling. According to the preparation method of the health-care chili sauce, centrifuge spin-drying is applied, so that the integrity of the raw materials is guaranteed, and the raw materials are not damaged; ultraviolet sterilization is applied, so that the safety of the product is guaranteed, and microorganisms capable of growing and germs capable of growing are completely destroyed. The health-care chili sauce has the advantages of improving appetite, tonifying spleen and stomach, expelling wind-damp, allaying fever, easing pain, reducing fat, enabling people to lose weight, and preventing cancerization.