The invention relates to a Chinese medicine composite for curing climacteric melancholia and an application thereof. The Chinese medicine composite is prepared from the following raw materials in parts by weight: 10-20 parts of radix rehmanniae praeparata, 10-20 parts of herba epimedii, 15-25 parts of radix paeoniae alba, 10-20 parts of uncaria, 25-35 parts of fossilia dentis mastodi and 25-35 parts of concha ostreae. The Chinese medicine composite disclosed by the invention accords with the assistant and guide principle of a traditional Chinese medicine on compatibility, and can be used for effectively harmonizing the balanced feedback function among hypothalamus, pituitary and ovarium in the curing process of the climacteric melancholia by being verified through animal and clinical experiments, thereby harmonizing the neuroendocrine network, relieving the anxious emotion, cognitive function, day and night change, mind retardance symptoms, sleep disorder, despairing concept and the like of a patient and effectively regulating and controlling the reproductive endocrine system and the immune system; the Chinese medicine composite disclosed by the invention has the advantages of small toxic side effect, less medicine variety and better curative effect, is suitable for being taken for a long time and is a medicine for safely and effectively curing the climacteric melancholia.