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Invention Publication
CN103391788A 灭活的脊髓灰质炎疫苗 有权 转让

灭活的脊髓灰质炎疫苗
Abstract:
本发明提供了减毒的脊髓灰质炎病毒，所述减毒的脊髓灰质炎病毒具有5′非编码区，所述5′非编码区由Sabin 3的5′非编码区组成，并被修饰以便其在结构域V的茎(a)或(b)中不具有碱基对错配，其中茎(a)和(b)中碱基对的七个或八个是U-A或A-U碱基对；及衣壳蛋白，所述衣壳蛋白来自Sabin 1、Mahoney、MEF或Saukett毒株。
Abstract(English):

The invention provides an attenuated polio virus having a 5' non-coding region consisting of the 5' non-coding region of Sabin 3, modified so that it does not have a base pair mismatch in stem (a) or (b) of domain V, wherein seven or eight of the base pairs in stems (a) and (b) are U-A or A-U base pairs; and a capsid protein from the Sabin 1, Mahoney, MEF or Saukett strain.

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