The invention discloses a large-width unit plate block curtain wall, and relates to the technical field of architectural engineering. The large-width unit plate block curtain wall comprises stand columns, middle columns, a glass plate block and screw rods. The middle columns are arranged among the adjacent stand columns, installation holes are formed in the middle columns, the screw rods penetrate through the installation holes, the two ends of each screw rod are fixed on the adjacent stand columns through nuts respectively, pretightening force is formed between the nuts on one side and the screw rods on the other side, and the glass plate block is fixed on the stand columns and the middle columns. According to the large-width unit plate block curtain wall, due to the fact that the middle columns which play a role in supporting are arranged in the middle of the glass plate block, the middle columns are connected with the stand columns through the screw rods, and a certain pretightening force exists between the screw rods on one side and the nuts on the other side, when the standing columns and the middle columns receive the stress of the glass plate block, the screw rods do not loosen and deform easily due to the pretightening force, and the whole curtain wall has high structural strength.