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发明公开
CN103298809A 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 有权

1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
摘要：
本发明涉及新的式(I)的三唑并[4,3-a]吡啶衍生物(I)，其中所有基团如权利要求书中所定义。本发明的化合物是代谢型谷氨酸受体亚型2(“mGluR2”)的正变构调节剂，其可用于治疗或预防与谷氨酸功能障碍有关的神经与精神障碍和其中涉及代谢型受体mGluR2亚型的疾病。本发明还涉及包含这类化合物的药物组合物、制备这类化合物和组合物的方法以及这类化合物用于预防或治疗其中涉及mGluR2的神经与精神障碍和疾病的用途。
摘要（英）：

The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 ('mGluR2'), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.

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