The invention relates to a clematis quinquefoliolata hutch-containing organic sterilizing and weeding compound fertilizer and a preparation method thereof. The compound fertilizer comprises raw materials in parts by weight as follows: 1-15 parts of stellera chameajasme, 5-10 parts of hops, 25-30 parts of pepper and 25-30 parts of gingko seed coats. The compound fertilizer has the characteristics of prevention and control of weeds in farmlands and broad-spectrum sterilization, compared with the prior art, the formulation provided by the invention has the characteristics that the weeding effect is good, the safety to the environment is achieved, weeds have less possibility of generating drug resistance and the like, and accordingly the application prospect is wide.