The invention discloses a lead and zinc separating method for high-oxidation-rate low-grade lead-zinc oxide ores. The lead and zinc separating method includes processes of raw material handling, roughing, screening, fine-screening and rescreening, and specifically includes: smashing and grinding the high-oxidation-rate low-grade lead-zinc oxide ores until the ores in -0.074millimeter accounts for 60-80% and reserving; adding vulcanizing agent, collecting agent and regulators to the treated high-oxidation-rate low-grade lead-zinc oxide ores for floatation and obtaining lead-zinc bulk rough concentrate and tailings; screening the lead-zinc mixed rough concentrate tailings by a 0.037mm fine screen and obtaining lead-zinc bulk concentrate I and screen underflows; subjecting the screen underflows to lead-zinc separation by positive-ion amine collecting agent and obtaining lead-zinc bulk concentrate II and tailings; mixing the lead-zinc bulk concentrate I and the lead-zinc bulk concentrate II to rescreen, and finally obtaining lead concentrate and zinc concentrate. The lead and zinc separating method is simple in processes, capable of sufficiently separating the high-oxidation-rate low-grade lead-zinc oxide ores, low in production cost and environment-friendly.