The invention relates to a method for neutralizing copper-sulfur mine acidic wastewater. First, lime or sodium hydroxide is added into a grinding machine, and grinding is carried out with crude ore; copper selection is carried out by sequentially adding water glass, aniline aerofloat, and ethionine ester; primary neutralization reaction is carried out with the acidic wastewater and copper tailing slurry; butyl xanthate and terpenic oil are added for selecting sulfur; lime or sodium hydroxide is added into sulfur tailing slurry, and a neutralization reaction is carried out again. The method is fast and convenient, and has the advantages of high adaptability and good effect. With the method, acidic wastewater can be effectively treated during a floatation process, and can reach a discharge standard. The method has important significance in ensuring mineral resource development sustainable development and avoiding environment pollution.