The invention discloses an ultrasonic atomization device which comprises an atomized liquid storage chamber for storing atomized liquid, and an atomization chamber communicated with the atomized liquid storage chamber by a first through hole (54), wherein a piezoelectric ceramic atomization sheet (4) is arranged on an external wall of the atomization chamber; a power supply device (518) supplies power to the piezoelectric ceramic atomization sheet (4); the ultrasonic atomization device further comprises a pressure regulation chamber; and a pressure regulation component (5) is arranged between the pressure regulation chamber and the atomized liquid storage chamber. The ultrasonic atomization device adopting a special structure decreases ionic compounds physically deposited in atomization micropores in the liquid, prevents an atomization element from long-term contact with the liquid, and prevents salt plasma compounds from being naturally deposited in the atomization micropores, the service life of the atomization device is prolonged, and the leakage of the atomized liquid is avoided. The atomization device integrates atomization, humidification and external charging, and is convenient and simple, and convenient to carry, and the practical value of the atomization device is improved.