The embodiment of the invention discloses a method and a device for sending an E-mail to multiple recipients. The method comprises the following steps of: copying the original E-mail according to the number of recipient addresses in the original E-mail to generate a plurality of E-mail transcripts, wherein each E-mail transcript only contains one recipient address, and different E-mail transcripts contain different recipient addresses; and sending a plurality of E-mail transcripts. By the embodiment of the invention, the same E-mail can be sent to multiple recipients simultaneously.