The invention discloses a dust-free equipment cabinet which comprises a cabinet body provided with a plurality of equipment installation grooves, and further comprises a first dedusting device. The cabinet body is provided with a gas inlet, the gas entering in the cabinet body flows through the gas inlet wholly, and a gas outlet of the first dedusting device is directly communicated with the gas inlet of the cabinet body. The gas in the cabinet body is wholly filtered through the first dedusting device, impurities of dust and the like in the gas cannot enter the cabinet body, cleanliness of circulation gas in the cabinet body is guaranteed, equipment of a power supply, a circuit board and the like in the cabinet body can operate under an approximately dustless environment, dust pollution is reduced, the probability of generation of short circuit due to the fact that the circuit board is affected with damp is reduced, the equipment in the cabinet body stably operates, and safe reliability of a system is high. At the same time, a machine room is not needed to be improved integrally, dustless requirements of a part of high precision equipment can be met, achieving cost is low, and popularization of the technology is benefited.