The invention relates to a TiO2 nano-tube drug sustained-release material with a PHA (phytohematoagglutinin) coating and application thereof. The drug sustained-release material is a TiO2 nano-tube of which a polyhydroxyalkanoate polymeric membrane is coated on the outer surface, and can be used for drug loading. Compared with the prior art, the PHA polymeric membrane is coated on the surface of the drug-loaded TiO2 nano-tube, so that the speed of a drug release process can be controlled, and the drug release time can be prolonged; and the method has the advantages of simple process, reliable effect, safe process and low cost.