The invention provides a medicine for controlling swine plague, belonging to the technical field of pharmaceutical and medical engineering. The medicine comprises the following components in parts by weight: 5-15 parts of isatis root, 5-15 parts of leaf of tasmanian bluegum, 5-15 parts of baical skullcap root, 5-15 parts of gypsum, 5-15 parts of common anemarrhena rhizome, 4-12 parts of radix sophorae tonkinensis, 4-12 parts of blackberry lily rhizome, 4-12 parts of air potato, 4-12 parts of oriental stephania root, 4-12 parts of great burdock achene, 3-9 parts of common bletilla rubber, 3-9 parts of callicarpa bodinieri, 3-9 parts of radix adenophorae, 3-9 parts of radix asparagi, 2-6 parts of platycodon root, 2-6 parts of liquorice, 2-6 parts of rhubarb and 2-6 parts of cape jasmine fruit. The medicine is prepared by drying the above Chinese herbal medicines in the sun, weighing the dried medicines, grinding the weighed medicines, sieving the powder with a 60-80-mesh sieve and mixing the powder uniformly. During clinical application, the medicine is soaked in boiling water for 30-60 minutes so that the active ingredients of the medicine are fully dissolved and precipitated to be beneficial to internal absorption of sick swine, and at the same time, the medicine efficacy can be improved by adding a few sugars and Vc. The medicine has higher clinical cure rate, does not have adverse reactions, medicine residues or medicine resistance hidden danger, has easily obtained needed raw materials, is simple in preparation method, is convenient to use and can be widely applied in the swine industry.