The invention relates to a permeation tank layered buried type diffusion aluminizing method for prevention of corrosion of the inner and outer walls of a heat exchange pipe, which is suitable for corrosion prevention of the inner and outer walls of a heat exchange pipe for a heat exchange device in the non HCL environment. The overall mechanical properties of the heat exchange pipe aluminized through the method basically remain unchanged, and the surface aluminized coating has excellent high temperature oxidation resistance and corrosion resistance, and also has good carburization resistance and hydrogen permeation resistance; the aluminized coating has excellent corrosion resistance to S, H2S, S02, S03 and RCOOH (naphthenic acid) at the high temperature of 240-500 DEG C, has excellent corrosion resistance to H2S, CO, CO2, NH3, HCN, HNO3, seawater and other media in the wet environment at the low temperature of 120 DEG C below, particularly to H2S, and also has a significant advantage on the performance price ratio of stainless steel; through the adoption of the structural form of the permeation tank and the blending ratio of the permeating agents, the process method is simple to operate, labor-saving and time-saving and little in environmental pollution; therefore, the method is widely used in various industries such as petroleum, chemicals, metallurgy and electric power.