The invention discloses health care medicinal liquor and a preparation method thereof. The formula of the health care medicinal liquor is as follows: 20-60 parts of sweet dew leaves, 20-80 parts of homalomena occulta, 20-100 parts of agastache rugosus, 15-60 parts of semen brassicae, 20-60 parts of corydalis tuber, 15-80 parts of berba epimedii, 20-80 parts of raspberry, 15-80 parts of cassia twig, 20-100 parts of polygonum multiflorum, 15-100 parts of glossy privet fruit, 30-100 parts of rehmannia glutinosa, 15-60 parts of astragalus mongholicus, 13-60 parts of fructus amomi, 10-80 parts of rhizoma cimicifugae, 15-150 parts of radix achyranthis bidentatae, 10-30 parts of schisandra chnensis, 20-50 parts of radix puerariae, and 200-500 parts of white wine. The preparation method has the following steps of dividing the white wine into two parts of 0.5-1.5:1.5-0.5 according to weight ratio; soaking other raw materials with the two parts sequentially; after 20-30 days of soaking each time, mixing the filtrate for twice soaking to obtain the health care medicinal liquor. The health care medicinal liquor is applicable to people having disease such as yang deficiency, yin deficiency and yin-yang deficiency, amnesia and insomnia, depressive symptom, weakness of the spleen and the stomach, recession of renal function, mental fatigue, blurring of image, spontaneous sweating and night sweat, baldness, premature graying of hair, pain from rheumatism, hands and feet cold, hypertension, hyperlipidemia, diabetes, and the like.