The invention relates to wall-broken Chinese herb medicine feed for prevention and cure of fish diseases and solves the problem that the conventional fish medicine for fish disease prevention and cure can only play a certain effect on one or more fish diseases caused by a certain pathogenetic agent and has poor prevention and cure effects on parasite diseases and the like. According to the technical scheme, the wall-broken Chinese herb medicine feed is prepared form the following raw materials in part by weight through ultramicro pulverization: 4.5-18 parts of radix sophorae flavescentis, 3-9 parts of fructus cnidii, 3-9 parts of radix scutellariae, 9-15 parts of radix isatidis, 3-6 parts of galla chinensis and 9-30 parts of radix astragali. The wall-broken Chinese herb medicine feed can be used for prevention and cure of various fish diseases, particularly parasite fish diseases, has a definite curative effect, can promote growth and development and improve fish immunity, produces no drug tolerance and has no toxic side effect.