The invention discloses a device and a method for micro-wave and vacuum ultra-filtrating integrated desalination of marinated egg white, belonging to the technical field of deep processing of subsidiary agricultural products. The device is composed of a micro-wave vacuum cavity, micro-wave sources, ultra-filtration pipes, fixing plates, a thermometer, a vacuum meter, a water circulating vacuum pump, an egg white delivery pump, a control panel, an egg white storage tank and a discharge valve, wherein the ultra-filtration pipes are channels for ultra-filtration and flowing of the marinated egg white; the micro-wave sources are evenly distributed around the micro-wave vacuum cavity; the ultra-filtration pipes are evenly arranged inside the micro-wave vacuum cavity and two ends of each ultra-filtration pipe are fixed by the fixing plates; the egg white storage tank is connected with an outlet of each ultra-filtration pipe inside the micro-wave vacuum cavity; the egg white delivery pump is arranged at the bottom of the micro-wave vacuum cavity and connected with an inlet of each ultra-filtration pipe and the egg white storage tank through a pipeline; and the water circulating vacuum pump is connected with the lower part of the micro-wave vacuum cavity through the pipeline. The micro-wave power, the temperature of egg white liquid and the vacuum degree inside the micro-wave vacuum cavity are automatically adjusted by the control panel. The device can achieve micro-wave treatment, ultra-filtration and flowing of the marinated egg white under a vacuum condition so as to achieve the purpose of effective and guaranteed desalination of the marinated egg white, and can process 100-500kg of marinated egg white per hour; the desalination rate of the marinated egg white can be up to be over 98%; and the desalination cycle is less than 1h, and the cost of large-scale production is lowered.