The invention discloses an application of compound prze-watanshinquinone B to preparing antitumor angiogenesis abnormal new drugs. An MTT experiment proves that the prze-watanshinquinone B can inhibit tumor cell proliferation, when drug concentration is 5.0-10.0mg/L, the cell proliferation activity is reduced remarkably; the chick embryo chorioallantoic membreme experiment proves that the prze-watanshinquinone B with the concentration of 10mg/L and 15mg/L can obviously inhibit angiogenesis of the chick embryo chorioallantoic membreme, so the prze-watanshinquinone B can be used for preparing the antitumor angiogenesis abnormal new drugs and has good curative effect and high safety, and is suitable for popularizing and using actually.