The invention provides a device and method for measuring pressure of a wall of an inclined shaft. The device comprises a pressure box support, soil body pressure boxes, a hose, a PVC (poly vinyl chloride) tube and signal transfer tubes, wherein the pressure box support is internally provided with the soil body pressure boxes, the soil body pressure boxes are closely contacted with a soil body, the pressure box support is connected with the PVC tube by virtue of the hose, the PVC tube is connected with the signal transfer tubes, and a signal transfer line of each soil body pressure box penetrates through the hose and the PVC tube and is led out from the signal transfer tubes, so that the soil body pressure boxes are firmly fixed, damage to the signal transfer lines of the soil body pressure boxes by a sliding-mode step and the like in a construction process can be avoided, water outside the wall of the inclined shaft can be effectively prevented from permeating into the wall of the inclined shaft along pipelines such as the PVC tube, and the measuring result accuracy is guaranteed.