The invention provides an integral squeezing steel strand anchorage stay rope and relates to a prestress stay rope and a manufacturing method thereof. The stay rope comprises a steel strand finished stay rope and an internal squeezing stay rope anchorage. The internal squeezing stay rope anchorage comprises a squeezing anchor cup, an adjusting nut and a sealing drum. A threaded hole, a taper hole and a straight hole are arranged in the squeezing anchor cup in sequence. A clamping piece is arranged in the taper hole. The conical degree of the outer surface of the clamping piece is identical with that of the inner surface of the taper hole. Steel strand holes are disposed in the clamping piece. Threads are arranged inside each steel strand hole. Sealant is filled between bare steel strands and the straight hole of the squeezing anchor cup and an inner hole of the sealing drum. The manufacturing method comprises the follow steps: (A) machining every part, component and the steel strand finished stay rope, (B) assembling, (C) threading the steel strands and installing the clamping piece, (D) squeezing, (E) installing an anti-loose screw plug, (F) sealing and filling the sealant. The integral squeezing steel strand anchorage stay rope and the manufacturing method thereof can reduce machining difficulty and production cost, and is reliable in anchoring performance and applicable for different specifications of the steel strands.