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CN102908441B 一种用于止痛的微乳型药物组合物凝胶膏剂及其制备方法 失效 - 权利终止

一种用于止痛的微乳型药物组合物凝胶膏剂及其制备方法
摘要：
本发明微乳型药物组合物凝胶膏剂表面无“泛油”现象，挥发性成分与凝胶膏剂中水溶性基质之间的相容性得到提高；透皮吸收实验结果表明，微乳形式促进了药物组合物凝胶膏剂中欧前胡素的透皮吸收，使其与阿魏酸的透皮吸收程度相近，微乳形式能够促使性质不同的成分同步透皮吸收；三种形式药物组合物凝胶膏剂初步稳定性实验结果表明，微乳形式有利于增强处方中挥发性成分的稳定性。
摘要（英）：

The invention relates to a micro-emulsion pharmaceutical composite gel ointment which is free of oil bleeding on surface. Computability of volatile components and water-soluble bases in the gel ointment is improved. As proved by transdermal absorption tests, transdermal absorption of imperatorin in the pharmaceutical composition gel ointment in the micro-emulsion form is improved, and is close to the transdermal absorption degree of ferulic fluid, and synchronously transdermal absorption of different components different in property can be improved by the micro-emulsion form. Besides, as proved by tests of preliminary stability of the micro-emulsion pharmaceutical composition gel ointment in three forms, the micro-emulsion form is favorable for enhancing stability of volatile components in the formula.

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