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CN102905724B 分枝杆菌抗原组合物 有权 转让

分枝杆菌抗原组合物
摘要：
本发明提供一种抗原组合物，所述抗原组合物包含：(a)第一分枝杆菌抗原多肽或第一分枝杆菌多核苷酸；和(b)第二分枝杆菌抗原多肽或第二分枝杆菌多核苷酸；其中：(i)所述第一分枝杆菌抗原多肽包含与SEQID NO：1或7的氨基酸序列具有至少70％的氨基酸序列同一性的多肽序列，或具有其至少7个连续氨基酸的其片段；(ii)所述第一分枝杆菌多核苷酸包含编码所述第一分枝杆菌抗原多肽的多核苷酸序列；(iii)所述第二分枝杆菌抗原多肽包含与SEQ ID NO：5的氨基酸序列具有至少70％的氨基酸序列同一性的多肽序列，或具有其至少7个连续氨基酸的其片段；和(iv)所述第二分枝杆菌多核苷酸包含编码所述第二分枝杆菌多肽的多核苷酸序列。
摘要（英）：

There is provided an antigenic composition comprising (a) a first mycobacterial antigenic polypeptide or a first mycobacterial polynucleotide; and (b) a second mycobacterial antigenic polypeptide or a second mycobacterial polynucleotide; wherein: (i) said first mycobacterial antigenic polypeptide comprises a polypeptide sequence having at least 70% amino acid sequence identity to the amino acid sequence of SEQ ID NO: 1 or 7, or a fragment thereof having at least 7 consecutive amino acids thereof; (ii) said first mycobacterial polynucleotide comprises a polynucleotide sequence encoding said first mycobacterial antigenic polypeptide; (iii) said second mycobacterial antigenic polypeptide comprises a polypeptide sequence having at least 70% amino acid sequence identity to the amino acid sequence of SEQ ID NO: 5, or a fragment thereof having at least 7 consecutive amino acids thereof; and (iv) said second mycobacterial polynucleotide comprises a polynucleotide sequence encoding said second mycobacterial polypeptide.

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