The invention discloses an efficient and practical clothes folding machine which comprises a rack, guide devices, a clothes supporting device and a clothes folding device, wherein the clothes supporting device is installed on the guide devices; the first guide device is arranged above the second guide device; the first guide device and the second guide device are both fixed on the rack; the first guide device and the second guide device both comprise an optical axis, an optical axis bracket and a sliding block; the optical axis is relatively fixed with the rack by the optical axis bracket; the optical axis is horizontal with a horizontal plane; the sliding block can be installed on the optical axis in a sliding mode; the clothes supporting device comprises a first plate and a second plate, wherein the first plate is used for supporting the body part of the clothes; the second plate is used for supporting folded clothes; the first plate is installed on the sliding block of the first guide device; the sleeves of the clothes hang from two edge gaps of the first plate; the lower half part of the clothes hang from the front end of the first plate; and the second plate is installed on the sliding block of the second guide device and is spatially positioned below the first plate to keep a set space distance with the first plate. According to the efficient and practical clothes folding machine disclosed by the invention, the structure is simplified, and the efficient and practical clothes folding machine is suitable for implementing automation.