Elastomer composition having a self-sealing property which can be used in particular as puncture-resistant layer in an inflatable article, based on at least (phr meaning parts by weight per 100 parts of solid elastomer): a blend of at least two solid elastomers, a polybutadiene or butadiene copolymer elastomer, referred to as “elastomer A”, and a natural rubber or synthetic polyisoprene elastomer, referred to as “elastomer B”, the elastomer A:elastomer B ratio by weight being within a range from 10:90 to 90:10; between 30 and 90 phr of a hydrocarbon resin; from 0 to less than 30 phr of filler. Inflatable article, such as a tire, provided with a puncture-resistant layer comprising a composition according to the invention; the puncture-resistant layer is advantageously used in combination with an airtight layer, for example based on butyl rubber or TPS elastomer, in order to form, in the inflatable article, an airtight and puncture-resistant laminate.