The invention relates to a family building and good family breeding method for channel catfish. The method comprises the following steps of: 1) building a channel catfish family: high-quality parent channel catfish with different germplasm resources are selected, the inbreeding is strictly controlled, the artificial directional mating technology is adopted for building the family through intraspecific hybridization, and each family is respectively subjected to hatching; and 2) screening channel catfish fast growing families: the three culture stages of the channel catfish seedling including the larva fish stage, the postlarva fish stage and the juvenile fish stage are regarded as the key stages for the channel catfish family breeding, the standardized culture is carried out, and the fast growing families are screened out through growth comparison. The method has the characteristics that the pertinency is strong, the breeding efficiency is high, the operation is simple, the effect is obvious, and the like. The built channel catfish family and the built good family breeding method open a new technology path for the high-yield good variety breeding of the channel catfish, and the good-family fish fry can be directly popularized and applied or can be used for breeding high-yield good varieties of the channel catfish.