The invention discloses a supercritical water oxidization treatment system for high-salinity organic waste water. The high-salinity waste water is subjected to cooling crystallization through cold energy of liquid oxygen to reduce mass concentration of inorganic salt in the waste water; a large amount of solid salt grains separated out from the waste water are removed by using a hydraulic cyclone device under a supercritical water condition to effectively prevent a subsequent pipeline and a reactor of the hydraulic cyclone device from plugging; and a desalting device is arranged at the lower part of the hydraulic cyclone device to continuously remove the inorganic salt from the system. In addition, excessive oxygen and CO2 product gas are recovered through a separation recovery part; the reaction time and the reaction temperature of supercritical water oxidization are reduced through arranging a simple subsequent treatment unit; and the system recovers heat energy of the reacted high-temperature fluid in a steam mode through the arrangement of a water softening device, so that the operation cost of the system is reduced. The system can be widely applied to the innocent treatment process of the high-salinity organic waste water.