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发明公开
CN102558600A 交联透明质酸海绵及其制备方法 无效 - 撤回

交联透明质酸海绵及其制备方法
摘要：
本发明提供一种制备交联透明质酸海绵的方法、以及该方法得到的海绵。方法包括(1)透明质酸原料溶胀于水中，得到透明质酸胶液；(2)调节透明质酸胶液为碱性，加入交联剂，进行交联反应，得到交联透明质酸凝胶；和(3)清洗所述交联透明质酸凝胶，并经低温冷冻干燥得到交联透明质酸海绵。本发明方法制备的交联透明质酸海绵，交联剂含量低，生物相容性好，体内降解周期与组织愈合周期一致，具有良好的止血、防粘连功能。
摘要（英）：

The invention provides a method for preparing a cross-linked hyaluronan sponge, and the sponge obtained by the method. The method comprises the following steps of: (1) swelling a hyaluronan raw material in water to obtain a hyaluronan gel fluid; (2) adjusting the hyaluronan gel fluid to be alkaline, adding a cross-linking agent, and performing cross-linking reaction to obtain a cross-linked hyaluronan gel; and (3) cleaning the cross-linked hyaluronan gel, and freeze-drying at a low temperature to obtain the cross-linked hyaluronan sponge. The cross-linked hyaluronan sponge prepared by the method provided by the invention is low in the content of the cross-linking agent, good in biocompatibility, consistent in in-vivo degradation cycle and tissue healing cycle, and good in blood-stopping and anti-adhesion functions.

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