The invention pertains to a skin wound healing material and a manufacturing method thereof. The skin wound healing material comprises a fluorinated hydrophobic film and at least one biocompatible macromolecule, wherein the fluorinated hydrophobic film is provided with a first surface and a second surface which are opposite to each other, the fluorinated hydrophobic film has air permeability and liquid impermeability, the at least one biocompatible macromolecule is formed at part of the first surface of the hydrophobic film by covalent bonding, and the water contact angle of the first surface where the biocompatible macromolecule is formed is below 40 DEG.