The invention provides application of a natural product, namely friedelin-3 beta-alcohol, to the preparation of vascular dementia-resisting medicaments. Tested by experiments on living animals, the friedelin-3 beta-alcohol can effectively inhibit histomorphology change of nerves of a rat with vascular dementia, improve the cognition, learning and memorizing ability of the rat with the vascular dementia, and obviously relieve vascular dementia symptoms.