The present invention relates to a device for medical and/or cosmetic treatment. The device includes positive and negative electrodes for administering an electrical stimulus to a nerve innervating opposed leg muscles of a patient, so as to cause isometric contraction of the muscles; a power supply connectable to the electrodes; and control means for activating the electrodes, wherein the device includes a flexible substrate on which are mounted the electrodes, the power supply, and the control means. The device of the invention can be used for reducing peripheral vascular resistance in the blood circulation of the patient, reducing or preventing diastolic flow reversal in an artery in the leg of the patient, prevention or avoidance of g-force induced loss of consciousness, diagnosing conditions characterised by increased peripheral vascular resistance, promoting circulation in the patient having a heart condition, modifying application of drugs for treating skeleton diseases, modifying administration of contrast agent, and implementing cosmetic treatment to the patient.