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CN102295685A 一种18F标记的PRGD2化合物、其药盒、药盒制备方法及应用 有权 转让

一种18F标记的PRGD2化合物、其药盒、药盒制备方法及应用
摘要：
一种18F标记的PRGD2化合物、其药盒、药盒制备方法及应用，涉及一种PET显像剂及制备方法和应用，属于放射性药物及核医学技术领域。所述药盒内包括NOTA-PRGD2和氯化铝，NOTA-PRGD2与氯化铝的摩尔比为（1～10）：1，采用冻干粉形式存在，初步研究表明，该药盒标记简单，操作方便，标记率高，成本低，耗时短，并且能使制备的配合物，18F-FAl-NOTA-PRGD2，具有与18F-FPPRGD2相同的生物性能，有望在临床上得以推广应用。
摘要（英）：

The invention relates to an 18F labeled PRGD2 compound, a kit thereof, a preparation method of the kit, and an application thereof. The invention relates to a PET imaging agent, a preparation method thereof, and an application thereof. The invention belongs to the technical field of radiopharmaceuticals and nuclear medicines. The kit comprises NOTA-PRGD2 and aluminum chloride, wherein a molar ratio of NOTA-PRGD2 to aluminum chloride is (1-10):1. NOTA-PRGD2 and aluminum chloride exist in states of lyophilized powders. As results of preliminary studies, the kit has advantages of simple labeling, convenient operation, high labeling rate, low cost, and low time consumption. With the kit, a prepared complex 18F-FAl-NOTA-PRGD2 has same biological properties with those of 18F-FPPRGD2. Therefore,the compound and the kit have potentials to be popularized for clinical application.

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