A cefodizime sodium hydrate, preparation method and uses thereof are disclosed. The said cefodizime sodium hydrate has better storage stability, and is applicable to pruduce medicaments for treating or preventing human or animals diseases of respiratory system infection, hepatobiliary system infection, five sense organs and urinary tract infections, abdominal cavity infection, pelvic infection, ichorrhemia, skin soft tissue infection, bones and joints infection, infection of adnexa uteri, intrauterine infection, parametrial infection, meningitis and gonorrhea and the like, which are caused by Gram-positive or negative bacteria.