A medication cassette uses a slidable core having a series of open top medication receiving cells extending in a length thereof. The core slides in an outer sleeve and includes a releasable locking arrangement for maintaining the core in a lock position with the sleeve closing the cells and movable to a release position allowing the core to slide relative to the sleeve. The release position allows the cells to be progressively exposed beyond the sleeve to allow medication to be removed. Both the slidable core and the sleeve are preferably made of a plastic material. The core is preferably a single component made by injection molding and the sleeve is preferably made as an extruded component.